The presence of fragrances is becoming more and more popular in almost every aspect of human lives. The content of selected and well-balanced perfumes mixtures in products daily used to clean, preserve and improve home and personal beauty can impact the approval by the consumer, conditioning the commercial success of the product itself.

As a consequence, the characterization of fragrances used in home and personal care (HPC) products is of primary importance for perfume industry for quality assessment, perfume formulation, competitors benchmarking, trace analysis of markers. Unraveling fragrances composition is a complex analytical task aiming to identify and quantify the composition of perfume raw materials, which are complex mixtures of synthetic and natural essential oils.

State-of-the-art of perfume formulation is based on specific Retention Index and deconvolution with dedicated MS libraries. The analytical approach is typically involving long capillary columns (i.e. 60m) with both polar and apolar stationary phases, with an overall analysis time of more than one hour for each injection. By translating the analytical method to faster separation, it is possible to significantly reduce the analysis time maintaining a reliable identification of the essential oils markers into the unknown blends.

This paper is focused on the benefits of a high speed GC-TOFMS for a high throughput approach, by using shorter and narrow bore columns.

In case of perfumes, direct liquid injection into the GC system is performed for fragrance profiling. When fragrances need to be characterized in more complex matrices as solid, semisolid or soapy samples, static headspace sampling technique can be successfully applied for an easy and clean extraction.


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